Endoscopic and pathologic features of Epstein-Barr virus–associated gastric carcinoma

Autor: Yanai, Hideo, Nishikawa, Jun, Mizugaki, Yuzo, Shimizu, Norio, Takada, Kenzo, Matsusaki, Keisuke, Toda, Tomohiro, Matsumoto, Yusuke, Tada, Masahiro, Okita, Kiwamu
Zdroj: Gastrointestinal Endoscopy; March 1997, Vol. 45 Issue: 3 p236-242, 7p
Abstrakt: Background:Although the presence of Epstein-Barr virus has been documented in approximately 7% of patients with gastric carcinoma, the clinical features of Epstein-Barr virus–associated carcinoma have not been well documented. We studied the histologic and endoscopic characteristics of Epstein-Barr virus–associated gastric carcinoma. Methods:We tested 124 gastric carcinomas from 117 patients using in situ hybridization for Epstein-Barr virus encoded small RNA1. The histologic and endoscopic findings in the Epstein-Barr virus–associated groups and the negative control groups were analyzed and compared. Results:Twelve tumors (9.7%) were identified as Epstein-Barr virus associated. These lesions were located mainly in the upper part of the stomach (p< .05) and had a diffuse-type histology (p< .05) compared with those in the control group. Six of seven (85.7%) early Epstein-Barr virus–associated lesions were type 0 IIc (superficial depressed) or a combined type, and 42.9% were accompanied by submucosal nodules of carcinoma with lymphoid stroma. Four of five (80%) advanced Epstein-Barr virus–associated tumors were type 3 (ulcerated without definite limits), thought to be the advanced shape of superficial depressed lesions. Conclusions:Epstein-Barr virus–associated gastric carcinomas often appear as superficial depressed or ulcerated lesions in the upper part of the stomach and have a diffuse-type histology with lymphoid infiltration. (Gastrointest Endosc 1997;45:236-42.)
Databáze: Supplemental Index
Externí odkaz: