| Autor: |
A. Harki, Daniel, D. Graci, Jason, E. Galarraga, Jessica, J. Chain, William, E. Cameron, Craig, R. Peterson, Blake |
| Zdroj: |
Journal of Medicinal Chemistry; October 2006, Vol. 49 Issue: 21 p6166-6169, 4p |
| Abstrakt: |
As part of our studies of lethal viral mutagens, a series of 5-substituted cytidine analogues were synthesized and evaluated for antiviral activity. Among the compounds examined, 5-nitrocytidine was effective against poliovirus (PV) and coxsackievirus B3 (CVB3) and exhibited greater activity than the clinically employed drug ribavirin. Instead of promoting viral mutagenesis, 5-nitrocytidine triphosphate inhibited PV RNA-dependent RNA polymerase (Kd1.1 ± 0.1 M), and this inhibition is sufficient to explain the observed antiviral activity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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