| Autor: |
A. Magnus, Nicholas, A. Staszak, Michael, E. Udodong, Uko, P. Wepsiec, James |
| Zdroj: |
Organic Process Research & Development; September 2006, Vol. 10 Issue: 5 p899-904, 6p |
| Abstrakt: |
Mild methods for conducting Knorr chemistry with -ketonitriles were developed. This enabled the preparation of 4-cyano-penta-substituted pyrroles and gave access to -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators for biological evaluation. In addition, a series of alkyl and aryl -ketonitriles were employed in Knorr cyclizations to probe steric tolerance and the possibility of direct introduction of aromatic moieties via Knorr chemistry. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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