| Autor: |
de Jesus Modesto, Marilza, Amer, Nadia Mohamad, Erichsen, Oscar, Hernandez, Sara, dos Santos, Cláudia Duarte, de Carvalho, Julienne Ângela Ramires, Pereira, Rosana Marques, França, Suzana Nesi, De Lacerda, Luiz |
| Zdroj: |
Journal of Pediatric Endocrinology & Metabolism; Sep2014, Vol. 27 Issue 6/10, p813-820, 8p |
| Abstrakt: |
We assessed body composition and muscle strength during the transition phase in 18 growth hormone (GH) deficient males treated with recombinant GH to final height and 18 controls. According to peak-stimulated GH and basal insulin-like growth factor-1 (IGF-1) during the transition phase, patients were subdivided into GH deficient (GHD-TP, n=9) and GH sufficient (GHS-TP, n=9) groups. Assessments included lean and fat body mass and bone mineral density (BMD), all measured by dual-energy X-ray absorptiometry, and dynamic knee muscle strength, assessed by isokinetic dynamometer. Total body and lumbar spine BMD and muscle strength were lower in GHD-TP patients when compared with GHS-TP and controls (all p<0.05), whereas lean and fat body mass were lower in both GHD-TP and GHS-TP patients when compared with controls (p<0.05). These findings suggest that administration of recombinant GH to final height is not sufficient to provide normal body composition and muscle strength in young male patients with GH deficiency. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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