| Autor: |
Kisaoglu, Abdullah, Ozogul, Bunyami, Turan, Mehmet Ibrahim, Yilmaz, Ismayil, Demiryilmaz, Ismail, Atamanalp, Sabri Selcuk, Bakan, Ebubekir, Suleyman, Halis |
| Předmět: |
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| Zdroj: |
Journal of the Chinese Medical Association; Sep2014, Vol. 77 Issue 9, p463-468, 6p |
| Abstrakt: |
Background This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N -acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. Results The results show that TPP and N -acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. Conclusion Thiamine pyrophosphate and N -acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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