| Autor: |
Choonharuangdej, Suwan, Amornvit, Pokpong, Srithavaj, Theerathavaj, Alam, Mohammad Khursheed |
| Zdroj: |
International Medical Journal; Jun2014, Vol. 21 Issue 3, p331-334, 4p |
| Abstrakt: |
Background: Relining tissue conditioner has become a reservoir for Candida species accumulation after long time utilization causing candidiasis commonly found in head and neck cancer patients. Objectives: This study aims to examine the inhibitory activity against Candida albicans of tissue conditioner being supplemented with Clinacanthus nutans , Caesalpinia sappan Linn, and Cymbopogon citratus (DC.) Stapf. Materials and Methods: Each herb was screened for their antifungal activity against C. albicans by agar disk diffusion method. Minimum Inhibitory Concentration (MIC) and Minimum fungicidal concentration (MFC) of individual and mixed herbs were then evaluated by micro-broth dilution and cultivation methods. Either individual or mixed herb was added to the liquid part of COE-COMFORT1'1 tissue conditioner prior to being prepared as manufacturer recommendation. Antifungal properties of herbs supplemented in tissue conditioner were analyzed from the absence of Candida colony. Results: Different degrees of antifungal activity against C. albicans ATCC 10231 were observed. C. citratus essential oil illus trated the greatest anti-candida effect and was followed consecutively by C. sappan Linn, and C. nutans. Mixed formulas of all three herbs demonstrated potent anti-candida activity. Interestingly, only C. citratus essential oil with high concentration as 4-time MIC and above mixed in the tissue conditioner exhibited antifungal activity against both reference and clinical strains of C. albicans. Conclusion: Both soluble and supplement forms of C. citratus essential oil have clearly displayed impressive anti -Candida effect. No antifungal effect was observed from the tissue conditioner supplemented with C. nutans and C. sappan Linn. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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