| Autor: |
Gordon Downie, Rosa Cuenca, Ron Allison, Brian McIlroy |
| Předmět: |
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| Zdroj: |
Journal of Bronchology; Jul2002, Vol. 9 Issue 3, p193-196, 4p |
| Abstrakt: |
A 58-year-old man with chronic obstructive pulmonary disease was evaluated for a proximal endobronchial-obstructing lesion. Computed tomography of the chest revealed collapse of the right lung and a large right paratracheal mass. Pulmonary assessment revealed stage 3B disease nonsmall cell carcinoma. Interventional bronchoscopic procedures included balloon dilation and self-expandable metal stent placement within the right mainstem and bronchus intermedius. Photodynamic therapy tumor ablation was used for a 2-cm right endotracheal mass 4 cm above the carina and a bulky lesion occluding the right mainstem bronchus and right upper lobe take-off. The smaller tracheal lesion was treated with standard dosimetry for a luminal lesion using a diffusing catheter to illuminate superficially. To optimize photodynamic therapy to the more bulky lesion, the diffusing catheter was placed interstitially into the center of the mass, and then treated. Superior tumor kill with less injury to surrounding normal mucosa was observed both clinically and histologically for the interstitial treatment compared with standard light delivery. The delivery of photodynamic therapy via interstitial placement of the light source may offer superior tumor necrosis, with potentially less intraluminal side effects compared with superficial light delivery for intraluminal neoplasms. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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