| Autor: |
Salahdeen, Hussein M., Idowu, Gbolahan O., Yemitan, Omoniyi K., Murtala, Babatunde A., Alada, Abdul-Rasak A. |
| Předmět: |
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| Zdroj: |
Journal of Basic & Clinical Physiology & Pharmacology; May2014, Vol. 25 Issue 2, p161-166, 6p |
| Abstrakt: |
Background: Tridax procumbens leaf extract has a folk reputation as an antihypertensive agent in Nigeria. Evidence suggests that it has a relaxant effect on smooth muscles. The present study was designed to investigate the role of calcium in the vasorelaxant effect of this extract. Methods: Concentration-response studies with noradrenaline (NA), KCl and CaCl2 were carried out in rat aortic rings with and without the extract in physiological salt solution (PSS) (n=6 each). Also, the role of intracellular calcium mobilization was studied by measuring the phasic response to NA in Ca2+-free N,N-ethylene glycol tetraacetic acid (EGTA) PSS (n=6). Results: The results showed that the contractile responses to either NA or KCl were attenuated (p<0.05) in the presence of the extract. Also, the extract attenuated the contractile response to CaCl2 in the presence of NA or KCl (p<0.05) in the Ca2+-free EGTA PSS, while the phasic response to NA was significantly (p<0.05) diminished. Conclusions: These results suggest that the vasorelaxant effect of T. procumbens leaf extract may be mediated by a non-specific, non-competitive inhibition of Ca2+ influx as well as by inhibition of Ca2+ mobilization from intracellular stores. This implies that it may contain vasorelaxant agents that may have calcium antagonistic potential. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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