Influence of FIO2 on PaCO2 During Noninvasive Ventilation in Patients With COPD.

Autor:	Savi, Augusto, Gasparetto Maccari, Juçcaro, Frederico Tonietto, Túlio, Peçanha Antonio, Ana Carolina, Pinheiro de Oliveira, Roselaine, Rieder, Marcelo de Mello, Zignani, Evelyn Cristina, Boschi da Silva, Émerson, Teixeira, Cassiano
Předmět:	OBSTRUCTIVE lung disease treatment ACADEMIC medical centers APACHE (Disease classification system) ARTIFICIAL respiration BLOOD gases analysis CARBON dioxide INTENSIVE care units LONGITUDINAL method OXYGEN therapy STATISTICS T-test (Statistics) DATA analysis DATA analysis software DESCRIPTIVE statistics GLASGOW Coma Scale
Zdroj:	Respiratory Care; Mar2014, Vol. 59 Issue 3, p383-387, 5p
Abstrakt:	BACKGROUND: The administration of a high FIO2 to COPD patients breathing spontaneously may result in hypercapnia, due to reversal of preexisting regional hypoxic pulmonary vasoconstriction, resulting in a greater dead space. Arterial blood gas trends have not been reported in these patients. In a 31-bed medical ICU in a teaching hospital we prospectively investigated the response of 17 CO2 -retaining COPD patients, after acute respiratory crisis stabilization with noninvasive ventilation, to an FIO2 of 1.0 for 40 min, after having been noninvasively ventilated with an FIO2 of ≤ 0.50 for 40 min. RESULTS: The mean ± SD baseline findings were: PaO2 101.4 ± 21.7 mm Hg, PaCO2 52.6 ± 10.4 mm Hg, breathing frequency 17.8 ± 3.7 breaths/min, tidal volume 601 ± 8 mL, and Glasgow coma score of 14.8 ± 0.3. PaO2 significantly increased (P < .001) when FIO2 was increased to 1.0, but there was no significant change in PaCO2, breathing frequency, tidal volume, or Glasgow coma score. CONCLUSIONS: During noninvasive ventilation with an FIO2 sufficient to maintain a normal PaO2, a further increase in FIO2 did not increase PaCO2 in our CO2 -retaining COPD patients. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
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