| Autor: |
Koch, Birgit C.P., Wildschut, Enno D., Goede, Anna L. de, Hoog, Matthijs de, Brüggemann, Roger J.M. |
| Zdroj: |
Medical Mycology Case Reports; Jan2013, Vol. 2, p23-24, 2p |
| Abstrakt: |
Abstract: Caspofungin, aechinocandin, is a relatively new lipophilic antifungal drug. Little is known concerning the pharmacokinetics of caspofungin in children. Extracorporeal membrane oxygenation (ECMO) allows prolonged cardiopulmonary support in patients with life-threatening respiratory or cardiac failure. Pharmacokinetics may be altered by ECMO. We describe the case of a paediatric patient on ECMO with severe pneumonia and sepsis, who had subtherapeutic exposure of caspofungin despite normal to high dosages of caspofungin. Therapeutic drug monitoring is warranted. [Copyright &y& Elsevier] |
| Databáze: |
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