The role of postoperative prophylactic antibiotics in the treatment of facial fractures: a randomized, double-blind, placebo-controlled pilot clinical study. Part 2: mandibular fractures in 59 patients.

Autor: Schaller, Benoit, Soong, Poh Luon, Zix, Jürgen, Iizuka, Tateyuki, Lieger, Olivier
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Zdroj: British Journal of Oral & Maxillofacial Surgery; Dec2013, Vol. 51 Issue 8, p803-807, 5p
Abstrakt: Abstract: The aim of this study was to evaluate the difference between a 5-day and a 1-day postoperative course of antibiotic on the incidence of infection after mandibular fractures involving the alveolus. Sixty-two patients with fractures of the mandible involving the dentoalveolar region were randomly assigned to 2 groups, both of which were given amoxicillin/clavulanic acid 1.2g intravenously every 8h from admission until 24h postoperatively. The 5-day group were then given amoxicillin/clavulanic acid 625mg orally every 8h for another 4 days. The 1-day group was given an oral placebo at the same intervals. Follow-up appointments were 1, 2, 4, 6, 12 weeks and 6 months postoperatively. Development of an infection was the primary end point. Fifty-nine of the 62 patients completed this study. Six of the 30 patients in the 5-day group (20%) and 6 out of the 29 in the 1-day group (21%) developed local wound infections. Three of the 6 in the 1-day group developed purulent discharge and swelling. One patient in the 5-day group developed a rash on the trunk. There were no significant differences in the incidence of infection or side effects between the groups. In fractures of the mandible involving the alveolus, a 1-day postoperative course of antibiotic is as effective in preventing infective complications as a 5-day regimen. [Copyright &y& Elsevier]
Databáze: Supplemental Index
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