| Autor: |
Buchanan, S. J., Davies, C. M., Florence, T. M., Stauber, J. L., Adams, M. S. |
| Zdroj: |
Water Supply (0735-1917); 1999, Vol. 17 Issue 3/4, p225, 0p |
| Abstrakt: |
The role of dietary aluminium in the aetiology of Alzheimer's disease remains controversial. Several epidemiological studies have associated the presence of aluminium in drinking water with the incidence ofAlzheimer's disease, despite the fact that water provides a relatively minor proportion of intake compared with other dietary sources. For aluminium from alum-treated drinking water to contribute significantly to blood aluminium, it would have to be much more bioavailable than aluminium from food. The relative bioavailabilities of aluminium naturally present in food and in alum-treated drinking water (ATW) were determined using 29 healthy volunteers. No increase (p>0.05) in aluminium in blood plasma of the volunteers was detectable after drinking 1.6 L/day of ATW (140 Mu g aluminium/L). However, due to the lower detection limit for aluminium in urine, a significant increase of 9% (p<0.01) in the daily excretion of aluminium in urine was found. Addition of citrate to the drinking water did not increase the daily excretion of aluminium, and neither age nor sex of the volunteers had an effect on aluminium excretion. The bioavailability of aluminium from ATW calculated from the urinary excretion data, was 0.37% of the total aluminium in ATW or 0.56% of the chemically labile fraction of aluminium in ATW The bioavailability of aluminium from food plus tea ranged from 0.2&0.64%, depending upon the assumed bioavailability of aluminium in tea. This suggests that the bioavailabilities of aluminium from food and ATW were similar. It was estimated that drinking 1.6 L/day of ATW containing 140 Mu g Al/L would contribute only 0.4-1.1% of the lifetime body burden of aluminium when 3 mg Al/day is consumed inthe diet. This is a minor proportion considering the relatively large and variable intake of aluminium from food by humans. [ABSTRACT FROM AUTHOR] |
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