| Autor: |
Schaefer, Brian A., Potter, Gerard A., Wood, Robbie, R.C.S., D.Orth., R.C.P.S, D. D. Orth., Burke, M. Danny |
| Předmět: |
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| Zdroj: |
Journal of Orthomolecular Medicine; 2012, Vol. 27 Issue 3, p131-138, 8p |
| Abstrakt: |
Salvestrols are naturally occurring, metabolically active substances that act as anticancer prodrugs when metabolically activated by the Cytochrome P450 enzyme, CYP1B1. They are phy-toalexins and as such are induced in response to pathogens. Asphytoalexins they do not fall neatly into any of the classes ofphytonutrients. Some are stilbenes, some are antioxidants, some are phytoestro-gens while others fall outside of these categories. Salvestrols obtain their anticancer activity not as a member of somephytonutrient class but rather through their metabolism by CYP1B1. Unfortunately, Salvestrols are deficient in western diets due to the modern agricultural practices that minimize the risk ofpredation through the use of fungicides with the consequence of minimizing the conditions for induction of these compounds. It is in organically grown foods that salvestrol levels are highest. To illustrate the breadth of a nutritional approach to cancer treatment using Salvestrols, cases are pre-sented here that cover stage 1 breast cancer, squamous cell carcinoma of the anus, chronic lymphocytic leukaemia, primary peritoneal carcinoma and a case of benign prostatic hyperplasia. Four of these cases highlight how rapidly one can recover once nutritional deficits are addressed without recourse to conventional treatment. [ABSTRACT FROM AUTHOR] |
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