| Autor: |
Pawar, Vinod S, Hugar, Shivakumar |
| Předmět: |
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| Zdroj: |
Asian Pacific Journal of Tropical Biomedicine; Jan2012 Supplement, Vol. 2 Issue s1, pS208-S211, 0p |
| Abstrakt: |
Abstract: Objective: To investigate the adaptogenic activity of methanolic extract of Trigonella foenum graecum seeds (METFGS) at 100, 250 and 500 mg/kg doses against anoxia stress tolerance in mice and immobilisation stress models. Methods: Withania somnifera (100 mg/kg, p.o.) was selected as reference standard and it showed significant effect in both stress models. The parameters like anoxia stress tolerance time was recorded in anoxia stress and estimation of biochemical marker levels and determination of organs weight were carried out in immobilisation stress model. Results: Concomitant treatment with METFGS at 500 mg/kg showed marked increase in anoxia stress tolerance time. But the lower doses (100 and 250 mg/kg) of METFGS produced mild increase in anoxia tolerance time. There was dose dependant significant reduction in biochemical parameters like serum glucose, cholesterol, triglycerides and BUN levels exhibited by test extract in immobilisation stress model as compared to stressed group. The stress induced increase in liver, adrenal gland weight and decrease in weight of spleen and testes were significantly reversed by the test extract at higher dose. But lower doses of extract caused the protective effect on weight of liver and adrenal gland only. Conclusion: The results from the present study indicate that METFGS possessed significant antistress activity. [Copyright &y& Elsevier] |
| Databáze: |
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