| Autor: |
Mousa, Sherif Abdo, Yassen, Amr Mohamed, Alhadary, Hala Salah, Sadek, Ehab El Saied, Abdel-Hady, EL-Said |
| Předmět: |
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| Zdroj: |
Egyptian Journal of Anaesthesia; Apr2012, Vol. 28 Issue 2, p125-132, 8p |
| Abstrakt: |
Abstract: Background: Oxytocin is uterotonic drug reducing uterine blood loss. Tranexamic acid reduce blood loss in various settings. Data on their efficacy are limited in gynecological hysteroscopy. This study was conducted to compare the effect of oxytocin versus tranexamic acid on hematological profile and transfusion requirement during hysteroscopic myomectomy (HM). Methods: Fifty women scheduled for HM were randomly assigned into two groups. Ttranexamic acid (TXA) or oxytocin (OXY). TXA was injected with 15mgkg−1 of tranexamic acid, followed by infusion of 10mgkg−1 h−1. In OXY, 10 Unites of oxytocin were added to 500mL saline (400mU/min) during surgery. Spinal anesthesia was induced for all patients. Hemodynamics, hematological data, number of transfusions, serum sodium and central venous pressure were measured. Results: TXA showed significant decrease of heart rate 30 and 45min and 1 and 2h when compared with OXY. Post operative Hb and Hct showed significant decrease (p <0.001) in TXA compared with OXY. CVP in TXA displayed significant increase (p <0.001) 15min after spinal blockade and 30min, 45min, 1h and 2h. Serum sodium showed significant decrease in TXA (p <0.001) compared with OXY nearly throughout study period. Conclusion: Use of oxytocin during HM was accompanied with stable hemodynamics, hematological profile and less transfusion requirement compared with the use of tranexamic acid. [Copyright &y& Elsevier] |
| Databáze: |
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