Endothelial Caveolar Hub Regulation of Adenosine Triphosphate--Induced Endothelial Nitric Oxide Synthase Subcellular Partitioning and Domain-Specific Phosphorylation.

Autor: Ramados, Jayanth, Wu-xiang Liao, Morschauser, Timothy J., Lopez, Gladys E., Patankar, Manish S., Dong-bao Chen, Magness, Ronald R.
Zdroj: Hypertension (0194911X); May2012, Vol. 59 Issue 5, p1052-1059, 8p
Abstrakt: The article explores uterine artery endothelial caveolae containing protein machinery related to subcellular partitioning in the absence or presence of adenosine triphosphate (ATP), and acting as focal hubs for nitric oxide (NO) and ATP-related proteins. Red blood cells, platelets and endothelial cells release ATP into the blood in response hypoxia, mechanical deformation and stress. Endothelial NO synthase (eNOS) is located in specialized protein-rich plasmalemmal invagination caveolae.
Databáze: Supplemental Index