Effect of Diffuse Panbronchiolitis Critical Region 1 Polymorphisms on the Risk of Aspirin-Exacerbated Respiratory Disease in Korean Asthmatics.
Autor: | Lee, Jin Sol, Bae, Joon Seol, Kim, Jeong-Hyun, Kim, Jason Yongha, Park, Tae Joon, Pasaje, Charisse Flerida A., Park, Byung-Lae, Cheong, Hyun Sub, Uh, Soo-Taek, Park, Jong-Sook, Park, Choon-Sik, Shin, Hyoung Doo |
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Předmět: |
BRONCHIOLE diseases
ASPIRIN ASTHMA CONFIDENCE intervals DRUG allergy EPIDEMIOLOGY GENES GENETIC polymorphisms LONGITUDINAL method REGRESSION analysis RESEARCH funding RESPIRATORY allergy RESPIRATORY distress syndrome GENETIC markers LOGISTIC regression analysis DATA analysis CASE-control method DATA analysis software DESCRIPTIVE statistics GENETICS |
Zdroj: | Respiratory Care; May2012, Vol. 57 Issue 5, p758-763, 6p, 1 Diagram, 4 Charts |
Abstrakt: | BACKGROUND:The functional role of the human diffuse panbronchiolitis critical region 1 (DPCR1) gene, located in the major histocompatibility complex class I, has not been widely investigated. However, this gene is a well known genetic marker for diffuse panbronchiolitis, a disease affecting human respiratory bronchioles. In this study we explored the association between polymorphisms in DPCR1 and aspirin-exacerbated respiratory disease (AERD), an asthma phenotype. METHODS: Genotyping of 6 polymorphisms was carried out in a total of 189 Korean asthmatic patients stratified into 93 AERD cases and 96 aspirin tolerant asthma controls. Subjects who exhibited significant decrease of FEV |
Databáze: | Supplemental Index |
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