Age and resting follicle number predict response to gonadotropin stimulation in in vitro fertilization cycles.

Autor: Addy, Douglas M., Whitman-Elia, Gail F., Queenan Jr., John T., Queenan, John T Jr
Předmět:
Zdroj: American Journal of Obstetrics & Gynecology; Aug2002, Vol. 187 Issue 2, p285-287, 3p, 1 Chart
Abstrakt: Objective: The purpose of this study was to assess whether age, resting follicle number, intraovarian blood flow, and/or ovarian volume are predictive of follicular response and oocyte quality in patients with in vitro fertilization.Study Design: A retrospective chart review was done on 90 in vitro fertilization cycles that were completed in a university setting. Multiple linear regression analysis was used to assess the predictive value of age, resting follicle number, pretreatment ovarian volume, and peak systolic velocity for response to gonadotropin stimulation.Results: Age was predictive (P <.05) for the number of oocytes retrieved, the number that reached two pronuclei, and the number of embryos that reached > or = 4 cells by day 3 after insemination. Resting follicle number was also predictive of follicular response and subsequent embryonic development. Peak systolic velocity and ovarian volume were both found to be of no value.Conclusion: Age and resting follicle number can be used as additional parameters to support patient counseling before in vitro fertilization stimulation. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index