| Autor: |
Reighard, Seth D., Sweet, Richard L., Vicetti Miguel, Claudia, Vicetti Miguel, Rodolfo D., Chivukula, Mamatha, Krishnamurti, Uma, Cherpes, Thomas L. |
| Předmět: |
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| Zdroj: |
American Journal of Obstetrics & Gynecology; Oct2011, Vol. 205 Issue 4, p324.e1-324.e7, 0p |
| Abstrakt: |
Objective: The objective of the study was to characterize endometrial inflammation associated with common genital tract pathogens. Study Design: The design of the study was the immunohistochemical characterization of the endometrial leukocyte subpopulations from 37 controls and 45 women infected with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis. Results: Compared with uninfected women, endocervical infection with C trachomatis, N gonorrhoeae, or T vaginalis was associated with significant increases in endometrial T cells, B cells, plasma cells, and polymorphonuclear leukocytes. Even more substantial increases in T cell, B cell, and plasma cell numbers were detected among women infected endocervically and endometrially with C trachomatis. Conclusion: Because lower genital tract C trachomatis, N gonorrhoeae, or T vaginalis infections were associated with comparable increases in the same endometrial leukocyte subpopulations, our results suggest the underappreciated involvement of T vaginalis in upper genital tract inflammatory processes. The more robust inflammatory infiltrate associated with C trachomatis endometrial ascension may offer insight into host inflammatory responses associated with pelvic inflammatory disease development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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