| Autor: |
Ogawa, Masahiro, Yamaji, Ryoichi, Mitani, Takakazu, Murata, Yohei, Nakao, Motoyuki, Harada, Naoki, Nakano, Yoshihisa, Inut, Hiroshi |
| Předmět: |
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| Zdroj: |
Bioscience, Biotechnology & Biochemistry; Sep2010, Vol. 74 Issue 9, p1965-1968, 4p |
| Abstrakt: |
The article focuses on the application of a yeast bioassay to study the interaction between NH2- and COOH (N–C) terminals of androgen receptors induced by androgens and anti-androgens. The bioassay, accordingly, uses a green fluorescent protein (GFP) as a reporter gene which however produces higher 50% effective concentration (EC50) values of various steroids. It adds the method was also effective in detecting compounds which inhibit the N–C interaction, such as resveratrol. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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