| Autor: |
Vesce, Fortunato, Buzzi, Marco, Ferretti, Maria Enrica, Pavan, Barbara, Bianciotto, Andrea, Jorizzo, Gianfranco, Biondi, Carla, Vesce, F, Buzzi, M, Ferretti, M E, Pavan, B, Bianciotto, A, Jorizzo, G, Biondi, C |
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| Zdroj: |
American Journal of Obstetrics & Gynecology; Apr98, Vol. 178 Issue 4, p759-764, 6p, 5 Graphs |
| Abstrakt: |
Objective: The effect of antibiotics in the prevention of preterm labor needs to be further investigated. The aim of this study was to determine the effect of ampicillin on prostaglandin E release from amnion as a possible explanation for its ability to retard preterm labor.Study Design: The effect of the beta-lactam antibiotic ampicillin on prostaglandin E release from human amnion was tested under basal and stimulated conditions.Results: Ampicillin dose dependently inhibits basal prostaglandin E release from amnion in both static and dynamic conditions. In our experiments, 10(-7) mol/L ampicillin (a concentration able to significantly inhibit prostaglandin E output) leaves the microbiologic features of the medium substantially unmodified up to 5 hours of incubation. Moreover, the drug reversibly counteracts the prostaglandin E elevation induced by arachidonic acid or oxytocin.Conclusion: This finding (i.e., that ampicillin inhibits prostaglandin E release from amnion) may offer an explanation for a beneficial response to ampicillin therapy in the case of preterm labor even in the absence of bacterial infection. [ABSTRACT FROM AUTHOR] |
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