| Autor: |
Jóźwicki, Wojciech, Skok, Zdzisław, Brożyna, Anna, Siekiera, Jerzy, Wolski, Zbigniew, Domaniewski, Jan |
| Předmět: |
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| Zdroj: |
Central European Journal of Urology; Sep2010, Vol. 63 Issue 3, p112-116, 5p, 1 Chart, 1 Graph |
| Abstrakt: |
Introduction. A tumor's histological organization is of prognostic importance. We evaluated the prognostic value of tumor uniformity (classic, or mixed = classic plus one non-classic type of differentiation as a histological variant) and non-classic differentiation number greater than 1 (NDN >1) in invasive urothelial cell carcinoma of the bladder. Material and methods. One hundred thirty-three bladders obtained after cystectomy for primary urothelial bladder cancer and classified as T1-4 were examined. Three elements in every tumor were histopathologically evaluated: non-classic differentiation type (NDT), extent of NDT (NDT%), and NDN. Ten ranges of non-classic differentiation were distinguished: from 0% (100% classic pattern) to over 50%. Based on accepted criteria every instance of NDT was diagnostically essential, even trace instances. Results. The percentage of tumors with pure classic (NDN = 0) differentiation was 16% (n = 21) and with non-classic (NDN >0) was 84% (n = 112). A tumor NDN of ≤2 was a factor that favorably influenced the prognosis (P = 0.024). No significant (P = 0.357) difference was observed between the lengths of survival of the groups with NDN = 0 and NDN = 1. Conclusions. The NDN of a urothelial tumor is of prognostic importance. The presence of uniform differentiation, i.e., NDN ≤1, is associated with a more favorable prognosis. The repeatability of the results of diagnostic and scientific examinations requires the complete consideration of every instance of non-classic differentiation in invasive urothelial cell carcinoma of the bladder, finding that a classic and/or one non-classic tissue (NDN <2) does not indicate the risk of neoplastic progression. [ABSTRACT FROM AUTHOR] |
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