| Autor: |
Antāne, Vita, Stonāns, Ilmārs, Rimeicāns, Jāzeps, Mangale, Māra, Brūveris, Zigmunds, Auzāns, Alberts, Mednis, Aleksandrs, Lūsis, Ivars |
| Předmět: |
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| Zdroj: |
Animals, Health, Food Hygiene: International Scientific Conference Proceedings; 2010, p5-11, 7p |
| Abstrakt: |
In 1984, the Institute of Organic Synthesis of Latvian Academy of Sciences developed a medical drug Mildronate that is widely used in medicine as anti-ishemic and stress-protective drug in treating various cardiovascular diseases, and in farm animals as growing and metabolic process stimulator. It is known, that Mildronate (Quaterin, Meldonium) interferes with carnitine biosynthesis, controlling carnitine and gamma-butyrobetaine (GBB) concentration ratio. L-carnitine is implicate in reproductive biology and could be associated with the maturation process of spermatogenesis. In its turn, GBB normalizes and stimulates the sexual activity and potency in mammals. The aim of our study was to estimate the influence of preparation Mildronate on spermatogenesis, libido and semen quality of boars. Two groups (control and experimental) of boars were used to achieve the task of the research. Each group consisted of six animals, were kept and fed at the same circumstances. Experimental period started two months later when the boars had reached the breeding preparedness. The boars of experimental group got orally 2 g of Mildronate daily for 60 days. Animals both control and experimental groups on a regular basis were tested for health status as well as the blood samples were taken. The semen was collected manually once every 10 days. The semen quality parameters were assessed before the administration of Mildronate and further once in 39 days that corresponds to the length of spermatogenesis cycle in boars. The sexual behavior was detected for each boar. The results of the study indicate that the administration of Mildronate in boars improves their sexual activity and the semen quality: time from approaching the „dummy" to the start of ejaculation is significantly (p<0.05) reduced and the progressive motility of spermatozoa is significantly increased (p<0.001). In animals that were administered Mildronate the dynamic changes of spermatozoa activity are more even and smoother with every semen collection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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