| Autor: |
Staten, Patrice L., Hines, Jeffrey F., Kost, Edward R., Fish, Mel, Rouse, Elizabeth, Hall, Kevin L., Staten, P L, Hines, J F, Kost, E R, Fish, M, Rouse, E, Hall, K L |
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| Zdroj: |
Journal of Lower Genital Tract Disease; Jan2000, Vol. 4 Issue 1, p30-33, 4p, 2 Charts |
| Abstrakt: |
Objectives: We set out to determine the clinical significance of atypical immature squamous metaplasia (AIM).Methods: We performed in a military, hospital-based colposcopy clinic a descriptive, retrospective review of patients who had a diagnosis of AIM. Patients were examined at 3- to 4-month intervals for at least 1 year after a diagnosis of AIM was established. A gynecological pathologist reviewed all histological and cytological specimens. Initial histological or cytological specimens were tested for the presence of HPV DNA using in situ hybridization.Results: High-risk HPV DNA types 16 or 18 were detected in 3% of patients with AIM. Concurrent cervical intraepithelial neoplasia 3 (CIN3) was noted in 3% of patients with AIM. One-third of patients with initially diagnosed AIM had complete resolution of this lesion after 1 year of follow-up.Conclusions: This descriptive, retrospective review shows that AIM does not appear to be associated with high-risk HPV DNA or with CIN3. In this limited study, a concurrent diagnosis of AIM likely does not influence the 1-year behavior of CIN. The degree of CIN should dictate treatment recommendations. A larger prospective trial is needed. [ABSTRACT FROM AUTHOR] |
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