Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers.

Autor: Dennis, Jessica, Ghadirian, Parviz, Little, Julian, Lubinski, Jan, Gronwald, Jacek, Kim-Sing, Charmaine, Foulkes, William, Moller, Pal, Lynch, Henry T., Neuhausen, Susan L., Domchek, Susan, Armel, Susan, Isaacs, Claudine, Tung, Nadine, Sweet, Kevin, Ainsworth, Peter, Sun, Ping, Krewski, Daniel, Narod, Steven
Předmět:
Zdroj: Breast; Dec2010, Vol. 19 Issue 6, p479-483, 5p
Abstrakt: Abstract: Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95% CI 0.70–0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95% CI 0.71–1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation. [Copyright &y& Elsevier]
Databáze: Supplemental Index
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