| Autor: |
SZÉCSI, M., ONDRÉ, DÓRA, TÓTH, I., MAGONY, S., WÖFLING, J., SCHNEIDER, G. Y., JULESZ, J. |
| Předmět: |
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| Zdroj: |
Acta Biologica Hungarica; Sep2010, Vol. 61 Issue 3, p274-281, 8p, 2 Diagrams, 1 Graph |
| Abstrakt: |
The article offers information on a study which determined the 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines using a radiosubstrate in vitro incubation method. The compounds reportedly contain several derivatized phenyl substituents linked to the exo-heterocyclic moiety. It mentions that the iozyme is involved in the metabolism of the androgen steroid hormones, while its inhibitors indicate a novel pharmacological treatment for several androgen-dependent diseases. |
| Databáze: |
Supplemental Index |
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