| Autor: |
Fuxue Chen, Da Zheng, Yaming Xu, Youqun Luo, Hong Li, Kangkang Yu, Yichao Song, Weiwei Zhong, Yonghua Ji |
| Zdroj: |
Journal of Pediatric Endocrinology & Metabolism; Jul2010, Vol. 23 Issue 7, p709-717, 9p, 2 Diagrams, 3 Graphs |
| Abstrakt: |
The article discusses a study that examined the use of Kir6.2-shRNA plasmid to down-regulate Kir6.2 expression in HIT-T15 cells. The study also determined the effect of Kir6.2 down-regulation on pancreatic beta cells, adenosine triphosphate (ATP)-sensitive potassium channel current, cytoplasmic free calcium influx and insulin secretion. It revealed the function of Kir6.2 subunits in electrophysiology characteristic, calcium influx, insulin secretion and RNA interference. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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