| Autor: |
YUKAWA, Miho, MORIWAKI, Hanae, MURAKAMI, Taichi, IKEDA, Hirohito, IWASE, Yukiko, AKI, Hatsumi |
| Předmět: |
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| Zdroj: |
Kobunshi Ronbunshu; 2010, Vol. 67 Issue 3, p192-197, 6p, 4 Diagrams, 1 Graph |
| Abstrakt: |
The inclusion complexes of two β-lactam antibiotics, ampicillin (ABPC) and amoxicillin (AMPC), with β-cyclodextrin in aqueous solution has been studied by semi-empirical molecular orbital method. In a strongly acid solution, two different types of complexes with a 1:1 stoichiometry were formed. Complex_Ph, in which the phenyl ring of β-lactam antibiotics was oriented towards the cavity of CD, and Complex_Pe, in which the penam ring was oriented towards the cavity. In neutral or basic solution, only Complex_Ph was formed. These results match the results of microcalorimetry and H NMR spectroscopy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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