Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including...
| Autor: | Wei-Sheng Huang, Chester A. Metcalf, Raji Sundaramoorthi, Yihan Wang, Dong Zou, R. Mathew Thomas, Xiaotian Zhu, Lisi Cai, David Wen, Shuangying Liu, Jan Romero, Jiwei Qi, Ingrid Chen, Geetha Banda, Scott P. Lentini, Sasmita Das, Qihong Xu, Jeff Keats, Frank Wang, Scott Wardwell |
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| Zdroj: | Journal of Medicinal Chemistry; Jun2010, Vol. 53 Issue 12, p4701-4719, 19p |
| Databáze: | Supplemental Index |
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