| Autor: |
Vardar, Saynur, Baylas, Haluk, Zihnioğlu, Figen, Emingil, Gülnur, Buduneli, Nurcan, Atilla, Gül |
| Předmět: |
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| Zdroj: |
Journal of Periodontology; Mar2004, Vol. 75 Issue 3, p393-398, 6p, 3 Charts |
| Abstrakt: |
Background: The aim of the present study was to investigate the total proteoglycan (PG) and chondroitin-4-sulfate (C4S) levels in gingival tissue samples obtained from patients with aggressive periodontitis (AgP) and chronic: periodontitis (CP) before therapy (baseline) and 1 month alter completion of non-surgical periodontal therapy. Methods: Gingival tissue samples were obtained from 10 AgP and 10 CP patients before initiation of treatment (baseline) and 1 month after non-surgical periodontal treatment. The control group comprised 10 systemically and periodontally healthy subjects. Total PG and C4S levels were determined by biochemical techniques. PG levels were analyzed using a modified Bitter and Muir method. C4S assay was carried out using chondroitin sulphate lyase AC and chondroitin-6 sulphate sulphohydrolase enzymes. The results were tested statistically using parametric tests. Results: The clinical periodontal parameters demonstrated significant decreases in the periodontitis groups (P <0.05) after treatment, and there was no significant difference between AgP and CP groups at baseline and after treatment (P >0.05). At baseline, total PG and C4S levels in both of the periodontitis groups were significantly lower than that of the control group (P-:0.05). One month after the non-surgical periodontal treatment, total PG levels in the periodontitis groups were comparable to the control group (P >0.05), whereas C4S levels in the AgP group were significantly lower than the other study groups (P <0.05). In the CP group, total PG and C4S levels increased significantly (P = 0.001 and P = 0.006, respectively) after non-surgical periodontal treatment, but they did not increase in the AgP group (P >0.05). Conclusion: The significant increases observed in total proteoglycan and chondroitin-4-sulfate levels after non-surgical periodontal treatment in the CP group but no: in the AgP group may suggest that healing patterns differ between the two periodontitis types in terms of PG and C4S composition of extracellular matrix. [ABSTRACT FROM AUTHOR] |
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