| Autor: |
Emingil, Gülnur, Atilla, Gül, Sorsa, Timo, Luoto, Hanne, Kirilmaz, Levent, Baylas, Haluk |
| Předmět: |
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| Zdroj: |
Journal of Periodontology; Jan2004, Vol. 75 Issue 1, p106-115, 10p, 6 Charts, 4 Graphs |
| Abstrakt: |
Background: Low-dose cloxycyclinc (LDD) is recognized to have non-antimicrobial properties that can therapeutically modulate the host response. The aim of the present randomized, double-blind, placebo-controlled, parallel-arm study was to examine the effectiveness of LDD in combination with non-surgical periodontal therapy, compared to non-surgical periodontal therapy alone, on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-6) levels and clinical parameters over a 12-month period in patients with chronic periodontitis. Methods: GCF samples were collected, and clinical parameters including probing depth (PD), clinical attachment level, gingival index (GI), and plaque index were recorded. Thirty chronic periodontitis patients were randomized either to a low-dose doxycycline (LDD) or placebo group. The LDD group received low-dose doxycydine (20 mg) b.i.d, for 3 months plus scaling and root planing (SRP), while the placebo group was given placebo capsules b.i.d. for 3 months plus SRP. The patients were evaluated every 3 months during the 12-month study period. At each visit, all clinical measurements and GCF sampling were repeated. GCF MMP-8 levels were determined by a time-resolved immunofluorescence assay. Intragroup comparisons were tested by the Friedman test followed by Wilcoxon signed-rank test to analyze significance of changes over time. The Mann-Whitney test was used to determine differences between the LDD and placebo groups. Results: Significant improvements were observed in all clinical parameters in both groups over The 12-month period (P<0.0125). The LDD group showed a significantly greater reduction in mean PD scores at 9 and 12 months and in mean GI scores at all time points than the placebo group (P<0.05). From baseline to 12 months, GCF MMP-8 levels were significantly reduced in both groups (P<0.0125). The GCF MMP-8 level in the LDD group was significantly lower than that of the placebo group at 6 months |P<0.05). Conclusions: The present results indicate that low-dose doxycycline therapy in combination with scaling and root planing can reduce GCF MMP-8 levels and improve clinical periodontal parameters in patients with chronic periodontitis. These results provide additional information about the usefulness of low-dose doxycycline therapy as an adjunct to non-surgical periodontal therapy in the long-term management of periodontal disease. The effectiveness and course of low-dose doxycycline therapy can be monitored conveniently by assessing GCF MMP-8 levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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