| Autor: |
Lomenick, Jefferson P., Calafat, Antonia M., Melguizo Castro, Maria S., Mier, Richard, Stenger, Peggy, Foster, Michael B., Wintergerst, Kupper A. |
| Zdroj: |
Journal of Pediatrics; Feb2010, Vol. 156 Issue 2, p221-225, 5p |
| Abstrakt: |
Objective: To determine whether phthalate exposure is associated with precocious puberty in girls. Study design: This was a multicenter cross-sectional study in which 28 girls with central precocious puberty (CPP) and 28 age- and race-matched prepubertal females were enrolled. Nine phthalate metabolites and creatinine were measured in spot urine samples from these 56 children. Results: Levels of 8 of the 9 phthalate metabolites were above the limit of detection (LOD) in all 56 subjects. Mono (2-ethylhexyl) phthalate (MEHP) was below the LOD in 25/56 samples (14 subjects with precocious puberty and 11 controls). No significant differences between the children with CPP and the controls in either absolute or creatinine-normalized concentrations of any of the 9 phthalate metabolites were measured. Conclusions: Although phthalates may be associated with certain other toxicities in humans, our study suggests that their exposure is not associated with precocious puberty in female children. [Copyright &y& Elsevier] |
| Databáze: |
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