| Abstrakt: |
Purpose: The purpose of this study was to assess the possible hepatotoxic effect of Teucrium polium (T. polium) lyophilisate in mice. Materials and methods: Inbred BALB/c adult male mice (20-25 g) were used in this study. T polium lyophilisate was administered orally to male mice. Serum alanine aminotransferase (ALT), gamma glutamyle transferase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), cholesterol, triglycerides and billirubin were determined to assess hepatotoxicity. Mice liver tissues were obtained and processed histopathologically in order to evaluate possible liver lesions. Results: Acute lyophilisate preparations exhibited a significant increase in serum enzymes: ALT, LDH, ALP and GGT. Meanwhile the chronic administration of doses of 0.1 and 0.2 g/kg of lyophilisate given orally for 30 consecutive days resulted in a significant increase in serum: LDH and ALP. Meanwhile, mice receiving different doses of lyophilisate exhibited lobar hepatitis, infiltration of lymphocytes, coagulation necrosis and fatty changes in the liver. [ABSTRACT FROM AUTHOR] |
