| Autor: |
Baskot, B., Obradovic, S., Rafajlovski, S., Jankovic, Z., Rusovic, S., Orozovic, V., Gligic, B., Ratkovic, N., Jung, R., Ivanovic, V., Bikicki, M. |
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| Zdroj: |
Contributions of Macedonian Academy of Sciences & Arts; 2008, Vol. 29 Issue 2, p243-256, 14p, 2 Color Photographs, 1 Black and White Photograph, 2 Diagrams, 6 Graphs |
| Abstrakt: |
The aim of this study was to determine and localize culprit lesion by myocardial perfusion imaging (MPI) in cases of angiographically detected coronary narrowing ≥ 75% of at least one coronary artery. Material and Methods: One hundred and thirty-two (132) patients with angiographically detected significant coronary narrowing (≥ 75% luminal stenosis of at least one major coronary artery) were studied. All the patients submitted MPI 99mTc-MIBI, with pharmacologic dipyridamole stress protocol with concomitant low level bicycle exercise 50W (DipyEX). We measured relative uptake 99mTc-MIBI for each myocardial segment using short-axis myocardial tomogram study. A 5-point scoring system was used to assess the difference between uptake degree in stress and rest studies for the same segments, and we created two indices: Sum reversibility score (SRS), Index of sum reversibility score (ISRS). Results: A total of 396 vascular territories (2244 segments) were analyzed before elective percutaneous coronary intervention (ePCI). Overall sensitivity, specificity and accuracy using SRS were 90.2%, 87.5%, and 89.4%, with a positive predictive value of 94.1%. Overall sensitivity, specificity, and accuracy using ISRS were 94.4%, 90.6%, 93.2% and the positive predictive value was 95.7%. Conclusion: DipyEX MPI with the two indices created, SRS and ISRS, significantly improves sensitivity, specificity and accuracy in the determination and localization of culprit lesions in patients undergoing elective PCI. [ABSTRACT FROM AUTHOR] |
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