| Autor: |
Liu, Man, Sanyal, Shamarendra, Ge Gao, Gurung, Iman S., Xiaodong Zhu, Gaconnet, Georgia, Kerchner, Laurie J., Shang, Lijuan L., Huang, Christopher L.-H., Grace, Andrew, London, Barry, Dudley, Jr., Samuel C. |
| Předmět: |
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| Zdroj: |
Circulation Research; 10/9/2009, Vol. 105 Issue 8, p737-745, 9p, 5 Graphs |
| Abstrakt: |
The article presents a study which examined the involvement of nicotinamide adenine dinucleotide (NADH) in the regulation of human cardiac sodium channels (NaV1.5). The study discussed the association of NaV1.5 mutations with Brugada syndrome (BrS.) The researchers used rate neonatal cardiomyocytes and HEK293 cells. The study revealed that pyridine nucleotides regulate NaV1.5, and suggested connection between NAD-dependent energy metabolism with sodium current. |
| Databáze: |
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