Progressive Rearrangement of Telomeric Sequences Added to Both the ITR Ends of the Yeast Linear pGKL Plasmid.

Autor:	Gunge, Norio, Takata, Hideki, Matsuura, Akira, Fukuda, Kohsai
Předmět:	YEAST PLASMIDS SACCHAROMYCES cerevisiae REARRANGEMENTS (Chemistry) CYTOPLASMIC inheritance
Zdroj:	Biological Procedures Online; 2008, Vol. 10 Issue 1, p29-42, 14p, 7 Diagrams, 1 Chart
Abstrakt:	The article discusses a study which examined the relocation into the nucleus of the yeast cytoplasmic linear plasmids using a monitor plasmid pCLU1. The nuclearly-relocated pCLU1 replicated in a linear form called pTLU-type plasmid in Saccharomyces cerevisiae, which carried the host telomeric repeats TG1-3 of 300-350 base pairs (bp) at both ends. It was observed that the intense rearrangement of telomeric DNA was closely associated with extreme instability of pTLU plasmids.
Databáze:	Supplemental Index
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