| Autor: |
Gołda, Ryszard, Jóźwicki, Wojciech, Przybylski, Grzegorz, Wolski, Zbigniew, Domaniewski, Jan, Wyszomirska, Małgorzata, Michałkiewicz, Jacek |
| Předmět: |
|
| Zdroj: |
Polish Journal of Urology / Urologia Polska; 2008, Vol. 61 Issue 3, p212-215, 4p, 1 Black and White Photograph, 1 Diagram, 2 Charts, 1 Graph |
| Abstrakt: |
The aim of the study. The detection, measurement and characterisation of circulating immune complexes (CIC) in tumour patients have shown both good and poor correlation with the progression of the disease. The origin of antigens consisting immune complexes in sera of examined cancer patients is unknown. Perhaps they are antigens specific for the cancer progress. Material and methods. The level as well as the characterisation (molecular mass) of the circulating immune complexes was estimated in the serum of 52 patients with renal cell cancer (G1 - 18, G2 - 21, and G3 grade - 13 patients), by means of polyethylene glycol (PEG) precipitation test. Results. The results were compared to the group of 45 healthy men. Elevated levels of CIC were observed in 44.2% of the patients with renal cell cancer. No seropositivity for CIC was observed in the control group. An increase in the seropositivity for CIC was observed in the patients with higher grade of renal cell cancer: the proportions of seropositive patients in the group of patients with G1, G2 and G3 phase of the disease were 27.7%, 52.4% and 53.8% appropriately. Molecular weight of the proteins of CIC was studied by SDS/PAGE and showed 28 bands of MW 20 - 231 kDa. The CIC originated from patients with renal cancer consisted of the proteins which were absent in healthy persons. Conclusions . Hence, the determination as well as the analysis of atypical proteins in the CIC, resulted from carcinogenesis, may improve a diagnostic procedure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
