Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses.

Autor: Crispi, Fatima, Hernandez-Andrade, Edgar, Pelsers, Maurice M.A.L., Plasencia, Walter, Benavides-Serralde, Jesus Andres, Eixarch, Elisenda, Le Noble, Ferdinand, Ahmed, Asif, Glatz, Jan F.C., Nicolaides, Kypros H., Gratacos, Eduard
Předmět:
Zdroj: American Journal of Obstetrics & Gynecology; Sep2008, Vol. 199 Issue 3, p254-254, 1p
Abstrakt: Objective: The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration. Study Design: One hundred twenty appropriate-for-gestational-age and 81 IUGR fetuses were classified in stages 1/2/3 according umbilical artery present/absent/reversed end-diastolic blood flow, respectively. Cardiac function was assessed by modified-myocardial performance index, early-to-late diastolic filling ratios, cardiac output, and cord blood B-type natriuretic peptide; myocardial cell damage was assessed by heart fatty acid–binding protein, troponin-I, and high-sensitivity C-reactive protein. Results: Modified-myocardial performance index, blood B-type natriuretic peptide, and early-to-late diastolic filling ratios were increased in a stage-dependent manner in IUGR fetuses, compared with appropriate-for-gestational-age fetuses. Heart fatty acid–binding protein levels were higher in IUGR fetuses at stage 3, compared with control fetuses. Cardiac output, troponin-I, and high-sensitivity C-reactive protein did not increase in IUGR fetuses at any stage. Conclusion: IUGR fetuses showed signs of cardiac dysfunction from early stages. Cardiac dysfunction deteriorates further with the progression of fetal compromise, together with the appearance of biochemical signs of cell damage. [Copyright &y& Elsevier]
Databáze: Supplemental Index
Externí odkaz: