| Autor: |
Bures, Jan, Kopin, Irwin, McEwen, Bruce, Pribram, Karl, Rosenblatt, Jay, Weiskranz, Lawrence, Corcoran, Michael E., Moshé, Solomon L., Barnes, Steven J., Pinel, John P. J. |
| Zdroj: |
Kindling 6; 2005, p295-303, 9p |
| Abstrakt: |
Conventional kindling experiments appear ideal for generating inadvertent conditioned effects: A variety of stimuli (e.g., removal from the home cage, attachment to the stimulation lead, and placement in the stimulation environment) are repeatedly presented to the animal prior to each stimulation and convulsion. We recently demonstrated that the stimulation environment can have a major impact on both kindled convulsions and interictal behaviour. Rats received periodic stimulations to the basolateral amygdala (BA) in one conditional environment (CS+) and an equal number of sham stimulations (the stimulation lead was attached but no current was delivered) in a second environment (CS−) in a quasirandom sequence. As kindling progressed, the rats became more defensive in the CS+ environment than in the CS− environment; and, when they were finally stimulated in the CS− environment, their convulsions were substantially less severe than in the CS+ environment.1 Furthermore, the kindled rats preferred the CS− environment to the CS+ environment in a subsequent conditioned place preference test. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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