| Autor: |
Bures, Jan, Kopin, Irwin, McEwen, Bruce, Pribram, Karl, Rosenblatt, Jay, Weiskranz, Lawrence, Corcoran, Michael E., Moshé, Solomon L., Chiba, Shigeru, Ishimoto, Takahiro, Ishimaru, Yuji, Tamura, Yoshiyuki, Nunomura, Akihiko |
| Zdroj: |
Kindling 6; 2005, p99-113, 15p |
| Abstrakt: |
Experimental studies suggest that the brainstem, particularly the brainstem reticular formation (RF), is involved in the secondary generalization of partial seizures originating in the forebrain. Electrolytic lesioning of the midbrain involving the medial part of the mesencephalic RF (MRF) prior to amygdala (AM) kindling retards the development of AM kindling.10 Extensive midline bisection of the brainstem (the midbrain to the pons) can inhibit the development of a stage 5 AM kindled seizure.8 In feline AM kindling, the emergence of afterdischarge (AD) in the ipsilateral and then contralateral midbrain reticular formation precedes generalization and synchronization of AD leading to the final stage 6 generalized convulsion.45 In addition, a unilateral lesion (ipsilateral to the kindled AM) in the midbrain reticular formation not only elevates the established generalized seizure triggering threshold but also prevents recalling the kindled stage 6 seizures in cats.45, 47 However, bisection of the forebrain commissures does not prevent stage 6 convulsive development.46 In prefrontal kindling in epileptic Senegalese baboons, Papio papio, bisynchronous electroencephalographic discharges in the bulbar RF are associated with photically induced generalized convulsions and AM kindled generalized seizures.44 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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