| Autor: |
Tarsy, Daniel, Paul, Robert H., Cohen, Ronald, Ott, Brian R., Salloway, Stephen, Stopa, Edward G., Zipser, Brian D., Donahue, John E. |
| Zdroj: |
Vascular Dementia; 2005, p257-265, 9p |
| Abstrakt: |
There is a growing consensus that microvascular damage is an important contributing factor to the pathogenesis of dementia (1). Increased vascular tortuosity and narrowing is a frequent consequence of normal aging and is significantly worsened by Alzheimer's disease (AD). Furthermore, late-onset sporadic AD, which comprises approximately 90% of AD cases, has been associated with homozy-gosity for the circulating plasma high-density lipoprotein apo E4. This chapter describes some of the recent work that has been conducted to suggest an association between damage to the microvascula-ture within the central nervous system (CNS) and AD development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
