| Autor: |
Hirabayashi, Yoshio, Igarashi, Yasuyuki, Merrill, Alfred H., Zeidan, Youssef, Marchesini, Norma, Hannun, Yusuf A. |
| Zdroj: |
Sphingolipid Biology; 2006, p167-181, 15p |
| Abstrakt: |
Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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