In Vivo Knockout of a Tissue-Specific Gene by Synthetic Ribozymes.

Autor: Walker, John M., Scanlon, Kevin J., Lyngstadaas, S. Petter, Sproat, Brian S., Blaschke, Martina, Ludwig, Janos, Rupp, Thomas, Prydz, Hans P.
Zdroj: Therapeutic Applications of Ribozymes; 1998, p371-386, 16p
Abstrakt: The enzymatic activity of RNA molecules has been a source of surprises ever since 1981 when Cech discovered this new aspect of RNA function (1,2). Its role as messenger and structural component in the translational process was suddenly transcended, and it is now evident that various RNA molecules can catalyze RNA splicing, ligation and, most importantly in the present context, cleavage of nucleic acids. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index