Biotinylated Primer for Detecting Telomerase Activity Without Amplification.

Autor: Walker, John M., Double, John A., Thompson, Michael J., Sun, Daekyu
Zdroj: Telomeres & Telomerase; 2002, p165-171, 7p
Abstrakt: The activation of telomerase, proposed as a critical set for cell immortalization to overcome cellular senescence, was believed to be associated with the malignant progression of human tumours (1-4). Therefore human telomerase appears to be an attractive new target for designing anti-cancer agents, as well as an important diagnostic marker of human cancer (5-7). For these reasons, it is necessary to develop telomerase assay methods that can be used for the quantitative measurement of telomerase activity. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index