| Autor: |
Buzdar, Aman U., Freedman, Ralph S., Hunt, Kelly K., Robb, Geoffrey L., Strom, Eric A., Ueno, Naoto T., Ready, Kaylene J., Arun, Banu K. |
| Zdroj: |
Breast Cancer 2nd edition; 2008, p57-81, 25p |
| Abstrakt: |
Hereditary predisposition to breast cancer accounts for approximately 5-10% of all breast cancers. The primary syndrome associated with an increased risk of breast cancer is hereditary breast and ovarian cancer syndrome, which is caused by mutations in the BRCA1 and BRCA2 genes. However, there are other hereditary cancer syndromes associated with an increased risk of breast cancer, including Li-Fraumeni syndrome, Cowden disease, Peutz-Jeghers syndrome, hereditary diffuse gastric cancer, and ataxia-telangiectasia. Genetic counseling and testing is a key component in the identification of individuals affected by these hereditary breast cancer syndromes. Genetic counseling is the process of educating patients and their families about inherited cancer risks based on their personal and family history and discussing the benefits, risks, limitations, and possible results of genetic testing. Once individuals are identified as having a hereditary breast cancer syndrome, they can be more effectively counseled regarding specific screening and prevention modalities, including chemoprevention and prophylactic surgeries. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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