| Autor: |
Antman, S. S., Marsden, J. E., Sirovich, L., Wiggins, S., Fall, Christopher P., Marland, Eric S., Wagner, John M., Tyson, John J., Keener, James P., Keizer, Joel E. |
| Zdroj: |
Computational Cell Biology; 2004, p77-100, 24p |
| Abstrakt: |
One of the hallmarks of cellular processes is their complexity. For example, in Chapter 3 we described a detailed model for the SERCA pump that might require 11 ODEs and 22 kinetic constants for its analysis. Similarly, the Hodgkin-Huxley model, which includes only three currents in the squid giant axon, involves 4 differential equations and information about three voltage gated currents. As complex as these processes are, they do not begin to represent the true complexity of cellular processes like muscle contraction or insulin secretion, which depend on the coupling of numerous dynamic components. In Chapter 5 we describe some examples of "whole-cell" modeling that attempt to deal with these larger issues. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
