| Autor: |
Esser, Karl, Howard, Richard J., Gow, Neil A. R., Ashford, A. E., Allaway, W. G. |
| Zdroj: |
Biology of the Fungal Cell; 2007, p49-86, 38p |
| Abstrakt: |
Motile tubular vacuole networks are normal features of cells at the growing tips of mycelial fungi. They store a range of nutrient elements including nitrogen and phosphorus, and new evidence supports their role as a conduit for nutrient transport. Delivery of protein to vacuoles, vacuole fusion and vacuole inheritance have been systematically dissected using yeast mutants deficient in specific activities, and using fluorescent probes including green fluorescent protein. Proteins are targeted to vacuoles via several intracellular pathways involving both tubules and vesicles. Vacuolar tubules permit transport of their contents by diffusion and by tubule motility, and the network of tubular vacuoles, particularly near the hyphal tip, ensures that material within vacuoles can be available throughout the cell. The microtubule cytoskeleton is important in tubule motility and positioning. The fungal vacuole can act as a detoxification compartment by pathways involving glutathione, and transport of toxin-complexes to vacuoles. Regulation of yeast cytoplasmic zinc levels involves vacuolar influx and efflux transporters. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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