| Autor: |
Walker, John M., Turner, Philip C., Cagnon, Laurence, Rossi, John |
| Zdroj: |
Ribozyme Protocols; 1997, p451-457, 7p |
| Abstrakt: |
Successful ribozyme-mediated gene therapy for HIV infection has to take into account several factors: 1.The therapeutic gene must interfere with or shut down the expression of essential viral genes.2.This requires a vector system for gene delivery and expression in HIV-sensitive cells.3.To bypass the high genetic variability of the HIV-1 replication process, the target sequence should be chosen in highly conserved sequences of HIV-1. These fortunately are mostly present in the essential regulatory genes (tat, rev) or sequences (PBS, U5), which are required to produce infectious viral particles (1). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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