| Autor: |
Back, Nathan, Cohen, Irun R., Lajtha, Abel, Lambris, John D., Paoletti, Rodolfo, Fagagna, Fabrizio d'Adda di, Chiocca, Susanna, McBlane, Fraser, Cavallaro, Ugo, Oehlmann, Maren, Mahon, Cathal, Nasheuer, Heinz-Peter |
| Zdroj: |
Advances in Molecular Oncology; 2007, p3-16, 14p |
| Abstrakt: |
DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: originlicensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and lagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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