Detection and Quantitation of Matrix Metalloproteases by Zymography.

Autor: Walker, John M., Bartlett, John M. S., Leber, Thomas M., Negus, Rupert P. M.
Zdroj: Ovarian Cancer (9780896035836); 2001, p509-514, 6p
Abstrakt: Matrix metalloproteases (MMPs) are a family of structurally and functionally related endopeptidases. They have in common a zinc ion at the active site and are released as an inactive proform (zymogen). Proteolytic activation enables MMPs to degrade components of the extracellular matrix such as collagens, fibronectin, and laminin [for review see (1-4)]. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index